How Long Does Codeine Stay in Your System?

What is Codeine?

Since the 90s of the last century, drug addiction has become a major problem in our society. Different types of drugs that cause addiction can no longer be counted on the fingers. Not realizing the gravity of the consequences, addicts are willing to eat anything to satisfy their desire. Today, many drug addicts are dependent on such a substance as codeine.

Codeine severe dry cough and irritating cough caused by various reasons, especially for a severe dry cough with chest pain. Because this product can inhibit the secretion of respiratory glands and ciliary movement, it should be used together with expectorant drugs for a severe cough with a small amount of sputum.

It can be used for pain relief with moderate pain — auxiliary medication during local anesthesia or general anesthesia, with a sedative effect.

On September 4, 2018, to further protect the safety of the public medication, the State Drug Administration decided to amend the “contraindications” and “children’s medications” for the code containing cold code. Among them, the relevant content in the “Contraindications” was revised to “disabling for young children under the age of 18”, and the relevant content in “Children’s medication” was revised to “Disable this product for children under 18 years old”.

How long does codeine stay in your urine?

As noted above, codeine is eliminated from the body rather quickly by The kidneys. On average, the material remains present in urine for 1-2 days.

Just how long does codeine appear in saliva?

Normally, the drug will drop below beneath testable levels in 1-2 days.

How long does codeine stay in the bloodstream?

Because of Its short half-life, codeine is generally detectable from the Blood for just 1 day. Therefore, it is not as commonly used for analyzing as other procedures.

The Effectiveness of hair testing depends on hair length and heaviness of drug usage. But, contrary to other testing procedures, it may take 1 to 3 weeks for the drug to show up following first ingestion.

Related: How Long Can Adderall Be Detected in Urine

Dependence on codeine

Codeine, many of us, know as a medicine that is used to treat a cough. It is part of such drugs as Nurofen, Kodterpin, Codelist, Solpadein, Pentalgin, Terpincod; it is very effective in inflammatory processes. Until 2012, codeine was released without a doctor’s prescription.

Many buyers of this wonderful analgesic and temperature-lowering medication were surprised when they learned that now a prescription is needed to purchase it.

This fact is explained by the fact that codeine is obtained from opium, as well as other opium drugs: morphine, heroin, methadone. Unlike the latter, it is a bit weaker, but also dangerous. For drug addicts there is no difference what drug to use, the result is essential for them-to get “high.”

They are not afraid of the fact that the use of codeine is addictive, as in the use of other drugs and causes great harm to the body. Treatment of codeine dependence is the same complex and the same long.

Codeine is a hidden danger

A ban on the sale of codeine introduced, but not all pharmacies perform it and sell codeine to everyone. Codeine is the only opioid drug freely sold in pharmacies; both adults and children can buy it.

Many people buy codeine and do not assume that it is a drug, the use of which can cause a stable dependence with regular intake. Dependence can develop slowly and imperceptibly for the consumer. Drug addicts, to achieve the intoxicating effect, drink at the reception not one or two tablets, and whole packs.

They are followed by a condition of strong intoxication, which may last up to 6-10 hours. At this time, people do not understand and do not think. After several such occurrences, there comes kazeinovaja dependence treatment where necessary.

Compared with heroin, codeine causes less euphoria, so drug addicts do not take it seriously and believe that a little pampered, throw it fun at any time. But the dependence on codeine is not as comic as many people think – it is a real drug addiction, which leads to serious consequences and health problems.

How to use codeine?

Oral way. The action of codeine is similar to the action of morphine, it also causes physical and mental dependence. When you take it inside, absorption is slower than with the injection method, and most of the excreted from the body. Therefore, the addict has to take a double and even triple and a large dose to achieve the desired effect.

Intramuscular method. When injecting codeine-intramuscularly, the substance is absorbed for 10-20 minutes. This rapid action of codeine is based on the replacement of opiate receptors, it quickly spreads to its destination and acts quickly, the introduced concentration remains in the body for a long time. With intramuscular use, dependence on the drug develops within a month.

Intravenous method. Is the most dangerous. Solutions prepared by drug addicts with codeine contain various impurities and chemical additives.

They are prepared by drug addicts in completely unsanitary conditions, the proportions of all substances are taken approximately and are, in fact, a poison that can cause poisoning, cause pulmonary edema, thrombus and the possibility of infection with various diseases: AIDS, Hepatitis, sexually transmitted diseases, etc.

Signs of drug intoxication with codeine

A person who uses codeine containing substances can be determined by his behavior and speech. With pills or syrup, scolopsis intravenously or intramuscularly, man differs inappropriate behavior.

He has a state of increased drowsiness, slow reaction to everything that happens, incoherent, confused thoughts, meaningless speech, retardation in actions. During the conversation, he closes his eyes, rolls them and is as if in a drowsy state, unable to maintain a conversation. But it responds well to touch and sharp sounds.

Having noticed such a state once or several times, it is necessary to react to the situation and begin to sound the alarm. Otherwise, your loved one can develop a strong dependence on codeine.

How to identify the fact of using codeine?

Drug tests are available to detect codeine use. They are easy and clear to use: one tip of the test strip is lowered into the urine or saliva. In the presence of codeine, the strip changes. A troublesome little way is laboratory tests of urine and saliva. The most expensive method – hair and nail analysis, which will show the use of the drug, even after a few months after the last use.

Where and how to treat codeine addiction?

All of the above leaves no doubt that the use of codeine is dangerous to health. It causes dependence which needs to be treated, breaks normal functioning of an organism, leads to a set of problems which need to be solved.

No drug addict could not get rid of kazeinovoj the dependencies yourself, so seriously may end up indulging a substance having a narcotic effect.

Solve problems with complicated disease kazeinovoj addiction we can help in our rehabilitation center in Krasnodar. The Lotus center is equipped with modern medical equipment. Only the best and only modern medicines and medicines are used to provide medical care.

The course of detoxification-purification of the body is painless and does not cause side effects: the physician, a dropper, vitamins, thisprocedure. Then feeds the addict in the capable hands of psychologists.

Psychological assistance is provided by professionals. For each patient, an individual rehabilitation program is developed, treatment is aimed at returning the person to a normal life, where there is no place for codeine and similar drugs.

The effect of codeine

If the substance enters the body, the effect of codeine comes in just a few minutes. But the “arrival” of the drug starts in an hour and lasts for 6 hours. In this case, the drug addict begins to feel:

• slackness;
• carelessness;
• unfounded euphoria.

But the side effects include indifference to the world. The peculiarity of this drug is that such feelings are accompanied by an acute heaviness in the limbs. Knowing this, addicts with the experience of taking him to a more comfortable position. Of course, addiction is not exactly develop, if you take the drug for a week, but after a month – get hooked on it very easily.

codeine, drug overdose help

Often drug addicts use codeine lying down because it causes a strong feeling of relaxation and heaviness in the limbs
In medicines to cure a usual headache, contains no more than 0.1 grams

. However, many have noticed that if the “dose” slightly increases, and the effect will be appropriate, growing into a dependence. But most drug addicts did not think about it, hoping that if this happens, it is not soon and not with him.

If you take the drug in shock doses, the drug addict immediately feels warm, and then there is a “blackout.” The main goal is achieved-the problems seem to go away.

The addict does not want to think and think. The addict becomes incredibly talkative, suddenly revives and laughs out of nowhere. Lost perseverance and he does not want to sit in one place. This condition provokes insomnia.

Consequences of abandonment of codeine

If a drug addict has been taking this drug for a long time, the withdrawal will take place for a long time, and it is incredibly painful.

And if the dependent has no willpower, then because of this “side effect,” he will resume taking the drug. Withdrawal syndrome depends on the” course of administration ” of the drug, as well as doses. It’s simple – the greater the dose and interval of use of codeine, the stronger and more painful will be the rejection of it.

The consequences of failure can be very different, but, as a rule, it is:

• cold sweat
• diarrhea
• vomiting
• a severe headache
• joint and heart pain
• bad dream
• convulsion
• depression
• apathy.

Such symptoms are accompanied by an exacerbation of pathological diseases and a sharp decrease in pressure. Do not forget that this drug, even in case of failure, destroys the body.

Problems with the gastrointestinal tract and liver – not uncommon, not to mention ulcers and gastritis. The average withdrawal interval varies from 11 days to 6 months.

Codeine withdrawal symptoms

If the physical symptoms of withdrawal have already subsided and almost do not manifest themselves, then the patient with rapid force begin to manifest mental disorders. It can include:

• Apathy
• Mania
• Loss of meaning in life
• Unfounded fear
• Hallucination

It was found that about 85% of drug addicts suffer from these disappointing diseases during the process of withdrawal.

But even if thus you decided to save a human, then often he develops schizophrenia or a psychopath. Frequent and attempts suicide. But during this period drug addicts especially lack warmth and support from their relatives. You should also seek qualified help from a specialist.

Treatment of codeine dependence

It also happens that, realizing the complexity of the situation, the patient suddenly realizes that he does not want such a life anymore, suddenly deciding to get rid of such a dangerous dependence.

But, even venturing to such measures, not everyone gets cured. And to get rid of dependence is not possible without the help of a qualified specialist. Treatment of codeine dependence requires a lot of time and costs.

Treatment of dependence on codeine, in the center of “the Decision.”

Even if a drug addict has gone through all the stages of withdrawal, it is very important to eradicate psychological addiction at the next stage. Special medications that the physician prescribes bring the residue from the body of drug addicts, so he soon returns to normal, sensing the obvious enlightenment.

But don’t underestimate the drug. If its action in the body is completed, then the psychological part of the issue is not so rosy. If a person again has some problems, which are very difficult to solve, then for him the only joy and purpose in life are pills, which, although for a short time, but relieve him of sad thoughts.

After finding such an easy way out of the situation, a person will resort to it again. Even subconsciously he will always think of it as a lifesaver.

Sample preparation

1. Preparation of reference solution

Accurately weigh the appropriate amount of codeine phosphate reference substance, dissolve it with mobile phase and quantitatively dilute to make a solution containing codeine 48/microglycol in 1 mL, which is the reference solution.

2. Preparation of test solution

Take 20 pieces of test sample, accurately weighed, finely weighed, accurately weighed the appropriate amount (about 12mg of codeine containing phosphoric acid), placed in a 50mL volumetric flask, add 2.5mL of water, ultrasonic to disintegrate, add methanol, ultrasound After treatment for 10 minutes, the codeine phosphate was dissolved, allowed to cool, diluted with methanol to the mark, shaken, filtered through a filter, and accurately weighed 2 mL of the filtrate, placed in a 10 mL volumetric flask, diluted with mobile phase to the mark, and shaken. It is the test solution.

Note: “Precision weighing” means that the weight should be accurate to one-thousandth of the weight weighed. “Precision measurement” means that the accuracy of the volume measurement should meet the accuracy requirements of the volumetric pipette in the national standard.

Operation steps: respectively accurately draw the reference solution and the test solution 10mL each, inject high-performance liquid chromatograph, measure with ultraviolet absorption detector at wavelength 220nm, codeine phosphate according to standard external method (C16H21NO3·H3PO4·3 /2H2O) Peak area calculated content.

Pharmacology

It can directly inhibit the cough center of the cerebral palsy. The antitussive effect is rapid and powerful, and its action intensity is about 1/4 of that of morphine. It also has an analgesic effect, about 1/12 to 1/7 of morphine, but stronger than general antipyretic analgesics.

Its analgesic, respiratory depression, constipation, tolerance, and addiction are all weaker than morphine. Oral absorption is fast and complete, and its bioavailability is 40% to 70%. After one oral administration, the plasma concentration reached a peak at about 1 hour, and t1/2 was about 3 to 4 hours.

Easy to pass through the blood-brain barrier and placenta, mainly in the liver combined with glucuronic acid, about 15% by demethylation to morphine. Its metabolites are mainly excreted in the urine.

Pharmacokinetics

Codeine and its salts are absorbed quickly and completely from the gastrointestinal tract after oral administration, and their bioavailability is 40% to 70%. It takes effect about 20 minutes after oral administration, and Tmax is about 1 hour.

It is metabolized by the liver in the body, mainly through the urine. About 10% of the dysfunction can be demethylated into morphine in the body, and T1/2 is 3 to 4 hours.

Tablets: more easily absorbed by the gastrointestinal tract after oral administration, mainly distributed in the lungs, liver, kidneys, and pancreas. This product is easy to pass through the blood-brain barrier and can pass through the placenta. The plasma protein binding rate is generally around 25%. T1/2 is about 2.5-4 hours.

The analgesic onset time is 30-45 minutes, with the strongest effect between 60-120 minutes: duration of action, analgesia for 4 hours, and antitussive for 4-6 hours. It is excreted by the kidney, mainly glucuronic acid conjugate.

Syrup: It is more easily absorbed by the gastrointestinal tract after oral administration, mainly in the lung, liver, kidney, and pancreas. This product is easy to pass through the blood-brain barrier and can pass through the placenta. The plasma protein binding rate is generally around 25%. T1/2 is about 2.5-4 hours.

The analgesic onset time is 30-45 minutes, with the strongest effect between 60-120 minutes: duration of action, analgesia for 4 hours, and antitussive for 4-6 hours. Excreted by the kidney, mainly glucuronic acid conjugate.

Usage and dosage

Due to different dosage forms and specifications, please read the instructions carefully or follow the doctor’s instructions.

Adverse reactions

Occasionally, nausea, vomiting, constipation and dizziness can also make the patient restless. See below for details:
1. More common adverse reactions are:
1 psychopathy or fantasy;
2 Breathing is weak, slow or irregular;
2 Heart rate is fast or slow, abnormal.
2. Uncommon adverse reactions:
1 convulsions, tinnitus, tremors or muscle movements that cannot be controlled;
2 urticaria; allergic reactions such as itching, rash or swollen face;
3 mental depression and muscle rigidity.
3. Long-term application can cause dependence. The tendency of the usual dose to cause dependence is weaker than other morphine drugs. Typical symptoms are: goose bumps, loss of appetite, diarrhea, toothache, nausea and vomiting, runny nose, chills, sneezing, yawning, sleep disturbance, stomach cramps, excessive sweating, weakness, heart rate, emotional agitation or unexplained causes Fever.

Pharmacopoeia Precautions

Pregnancy class C. Excessive convulsions in children can be countered by naloxone. A continuous application can be addictive. More viscous patients should be used with caution. Patients with obstructive pulmonary disease such as bronchial asthma cough and poor airway emphysema are banned. Patients who are allergic to this product are prohibited.

The following situations should be used with caution:

(1) bronchial asthma;
(2) Acute abdomen, when the diagnosis is not clear, may be misdiagnosed because of covering the truth;
(3) gallstones can cause bile duct fistula;
(4) Unexplained diarrhea can weaken the intestinal peristalsis and alleviate the symptoms of diarrhea and misdiagnose;
(5) craniocerebral trauma or intracranial lesions, this product can cause pupils to become smaller, blurred clinical signs;
(6) Causes of prostatic hypertrophy This product is easy to cause urinary retention and aggravate the condition.
(7) Repeated administration can produce drug resistance, and it is addictive for a long time.

Pregnant women and lactating women

(1) This product can pass through the placenta, making the fetus addicted, causing withdrawal symptoms such as excessive crying, sneezing, yawning, diarrhea, vomiting, etc. Application of this product during childbirth can cause neonatal respiratory depression.
(2) It can be excreted from milk and used

medicine interactions

(1) When combined with anticholinergic drugs, this product can aggravate the adverse reactions of constipation or urinary retention.
(2) When combined with methadone or other morphine central inhibitors, it can aggravate central respiratory depression.
(3) When combined with muscle relaxants, respiratory depression is more pronounced.
(4) This product inhibits the metabolism of zidovudine and avoids the combination of the two.
(5) Combined with methaqualone, it can enhance the antitussive and analgesic effects of this product.
(6) This product can enhance the analgesic effect of antipyretic and analgesic drugs.
(7) Combined with barbiturates, it can aggravate central inhibition.
(8) In combination with cimetidine, it can induce mental confusion, disorientation and shortness of breath.