How Long Does Nyquil Stay in Your System?

How long does Nyquil take to work?

When you have a sore throat or have an allergy attack, Nyquil proves to be the most effective over-the-counter remedy to correct it. While it is effective in dealing with such conditions, it does not come without side effects.

The dreaded Nyquil Hangover is one of them, like drinking alcohol or taking any medication that can alter your body’s chemistry, there are often sequels that can make you wonder the urge to take them in the first place.

With this guide in oneHOWTO, you will get complete information on the effects of Nyquil, and how long does Nyquil last.

What is Nyquil?

Nyquil consists of two drugs, dextromethorphan, and chlorpheniramine. It is an antihistamine, and the other is a suppressive cough. It is a popular and effective over-the-counter medication used to treat flu symptoms, allergies, and common cold.

The word ‘Nyquil’ is a combination of ‘night’ and ‘quiet,’ which indicates that it should be used at night and it works by maximizing tranquility and help induce sleep.

It allows you to sleep without interruption and you do not wake up frequently due to disturbances. It also contains doxylamine succinate which is found to be effective in maintaining sleep if you have certain diseases.

When to take Nyquil?

Nyquil is an OTC (over the counter) medication that is used to treat flu symptoms and common constipation such as sore throat, sneezing, minor aches and pains, headache, runny nose, cough, and fever.

That means you do not need a prescription to buy it. The best time to take Nyquil is before bed because it contains sedatives that help you to get sleep and rest you need to fight the symptoms.

If you take it at other times, when you are not going to sleep it can affect your behavior and ability to stay awake. Do not drive or operate heavy machinery if you have taken Nyquil and do not know the effect it can have on your body.

Side effects of Nyquil

Although Nyquil is available over the counter without a prescription and is generally considered as a safe product to use, it comes with some side effects. Some of them are:

  • Dizziness
  • Extreme drowsiness
  • Nervousness and anxiety
  • Excitability
  • Weakness and fatigue
  • Loss of appetite
  • Diarrhea or constipation
  • Vomiting and stomach pain
  • Hangover

These side effects can be potentially dangerous when driving, operating machinery or doing any other type of activities that require attention and alertness. That is why it is always recommended to be taken at night.

If you need to take it during the day, make sure that you stay home and take rest after taking your Nyquil dose.

Nyquil variations

There are some Nyquil variations available out there:

  • Nyquil: The standard product, which contains paracetamol, which relieves pain and reduces fever, dextromethorphan, which suppresses cough and succinate doxylamine to induce sleep.
  • Nyquil Grave: This stronger version of Nyquil contains all the ingredients of the main drug but with a dose of phenylephrine. It is an effective form of nasal decongestant that relieves your symptoms cold at night.
  • Nyquil Cough: It does not contain paracetamol but has doxylamine succinate and dextromethorphan to relieve cough.
  • DayQuil: This variation is suitable to be taken during the day. It contains paracetamol and phenylephrine, but not antihistamines and low dosage of dextromethorphan. Due to its composition, you can keep it awake without napping.
  • ZzzQuil: It contains diphenhydramine which is effective in dealing with various cold symptoms and allergies, such as itching, runny nose, sneezing, hives.
  • QlearQuil: There are four different variations of QlearQuil, all of which are intended to alleviate the symptoms of allergies. Its variations are the Night Allergy Relief, All Day and Night All 24 Hours Allergy Relief, Night and Sinus And the decongestion and the Sinus Day And the decongestion.

How Long Does Nyquil Take to Start Working?

Nyquil starts working almost immediately. If you take liquid Nyquil, you will immediately experience a feeling of heat running down your throat. It feels more like you’ve just taken a shot of something. Nyquil tablets take about 8-10 minutes to start showing effects.

Your whole body will feel warm, and your pains will begin to fade. Soon, you will feel your eyelids drooping, and I feel the dire need to sleep. At this point, you should lie on your bed, slide under the blanket and allow the drug to make you sleep.

When you wake up, you will have heavy eyes and difficulty focusing. This hangover will probably keep you dizzy for at least the beginning of the day, after which you should be ready to get back to work.

How long do Nyquil effects last?

If you want to know how long Nyquil effects last, you need to learn about the different ingredients present in the medication.

Although all Nyquil formulations contain doxylamine succinate to induce sleep, you need to know the half-lives of other ingredients to determine how long they will stay in your system:

  • Doxylamine Succinate: This ingredient is present in all variations of Nyquil, and 50% stays for about 10 hours in the body of a healthy adult. It means that 50% of what is eliminated from your systemic circulation after 10 hours and more than half lives is eliminated in about 2.25 days.
  • Paracetamol : All Nyquil variations except Nyquil Cough, contain this ingredient. 50% of the drug is eliminated from your system within 1-4 hours but usually takes 2 to 3 hours in healthy adults. Thus, it can be estimated that all this is eliminated from your boy only after 22 hours of consumption.
  • Dextromethorphan: Also known as DXM, 50% of the drug is eliminated only after 3 to 6 hours, and all this is only removed after 11-33 hours.
  • Phenylephrine: Nyquil variations that are formulated to remove congestion of nasal passages contain this ingredient. Having a short half-life, 50% of it is eliminated within 2-3 hours. All drug is withdrawn between 6 and 18 hours after ingestion.
  • Pseudoephedrine: This is another ingredient used for decongesting nasal passages. 50% of what is normally removed from your body after 2 to 21 hours, depending on your age and the pH of the urine. On average, this happens after about 6 hours in a healthy adult. Most people will remove all interactions from their system in about 33 hours after consuming

Now that we know the half-life of all drugs present in Nyquil, we can identify that doxylamine succinate remains in your system for a longer period.

It takes about 2.25 days to eliminate your system. Since all Nyquil variations contain this drug, they can keep you feeling sleepy for several 2-3 days after taking it.

Factors that influence how long Nyquil will stay in your system

Several factors affect how long Nyquil will stay in your system:

  • Age: The age of the user can significantly alter the pharmacokinetics of different ingredients. For example, poor, elderly patients and liver function hire, due to which they may face the side effects for longer.
  • Body Mass: Doxylamine succinate present in Nyquil is fat soluble. So if you have a high percentage of body fat, more of the drug will be accumulated in your system, and you will experience its effects for longer.
  • Levels of glutathione: Individuals with reduced or low levels of glutathione will accumulate more of the drug, and it will take longer for them to eliminate it.
  • Metabolism: People with high metabolic rate will burn and use the drug faster than those with a slow metabolism.
  • Dosage: The larger the dose, the longer it will take to eliminate from your systemic circulation.
  • A frequency of administration: The frequency of taking Nyquil and how much time you have taken will also affect how long will last in your system. It is because your body builds up a tolerance, just as if you take most things (like alcohol), you can develop a tolerance.
  • Co-administration of other medications: Other medications you take along with Nyquil also affect the duration of time for which it will remain in your system.

This article is for informational purposes only; oneHOWTO has no authority to prescribe any medical treatment or to create a diagnosis. We invite you to visit your doctor if you have any illness or pain.