How Long Does Tramadol Stay in Your Blood?

Tramadol is an analgesic from the group of opioid analgesics.

The drug has a psychoactive effect and comes in different forms: tablets, capsules, suppositories, injections.

Excess dosage, frequent use of the drug leads to a state of drug intoxication.

Short-term reception, taking into account the dosage prescribed by a qualified specialist, does not cause addiction.

Let’s consider how much tramadol in the blood and urine is held, based on the responses of the narcologist.

Where most often tramadol settles in the human body?

Attachment to Tramadol may develop from the first dose if the dosage of the ingested substance is large.

When systematically used for the development of resistant dependence takes about 2-3 months.

In some cases, Tramadol is used as drug replacement therapy to reduce withdrawal, but this approach leads to the emergence of a new addiction.

The destructive effect on the systems and organs of Tramadol begins in a month of use.

Tramadol is considered a dangerous narcotic substance. After a month of use, changes begin on the part of organs and systems.

Initially, the patient complains of loss of appetite and the emergence of thirst, then manifest headaches.

The well-being of a drug addict is rapidly deteriorating, in particular:
  • 3-month use of opioid leads to problems with the digestive tract, nervous system (the mood of the addict becomes changeable).
  • For 1 year, the drug can have an adverse effect on the entire body (development of dystrophy, baldness, increased fragility of bones, disruption of the central nervous system).
  • Over a year of use, the risk of overdose with a subsequent death increases by 2 times. Drug-dependent people face serious mental disorders; the hepatobiliary system suffers (the liver is destroyed).

Getting rid of opioid dependence is quite difficult. The duration of rehabilitation is influenced by the following factors:

  1. age of the patient
  2. health status
  3. a dosage of the drug used
  4. duration of dependence
  5. a rate of exchange processes.

How much does Tramadol in the body? Usually for the initial detoxification will take from 2 to 4 weeks.

At this stage, only physical dependence is eliminated. With decay products, the situation is different. For a complete cleansing of the body will take about 20 years.

The treatment is carried out in several stages under the strict supervision of a narcologist. Subject to all recommendations, the chances of a complete cure are 70-75%.

How long does tramadol in the body?

How Long Does Tramadol Stay in Your Blood?

The effect of the substance begins 1-2 minutes after drinking. There comes the euphoria, excessive activity.

This state persists for 12-36 hours. As you get used to the effect of tramadol is reduced, the feeling of buzz passes in 5 minutes.

The time of the drug effect of Tramadol depends on the duration of use.

Euphoria is replaced by a feeling of loneliness. Nightmares haunt drug addicts, paranoia and mania develop.

How long does tramadol stay in your blood?

How Long Does Tramadol Stay in Your Blood?

One of the most frequent questions: how much tramadol is kept in blood?

When taken once, the opioid is present in the blood plasma for about 2 days, with systemic – longer.

Laboratory blood tests can detect residues for several months (at least 3).

How long does tramadol stay in your Urine?

How much tramadol is kept in the urine? In urine tramadol and its metabolites are contained within 7 days.

These data are considered relative and are directly dependent on individual factors and characteristics of the administration of Tramadol.

The definition of Tramadol in blood and urine depends on the amount and duration of use.

How long does tramadol in blood and urine? Answer this question just can not.

The semi-excretion period of a drug directly depends on the duration and regularity of consumption, the patient having problems with the urinary system.

How and what to accelerate the withdrawal of tramadol?

In clinical addiction, the following methods are used to speed up the withdrawal of tramadol:

  1. Balanced diet. Food should be natural, containing all the necessary vitamins and minerals.
  2. It is advisable to exercise regularly about physical abilities. Training is conducted under the obligatory supervision of an oreabilitologist.
  3. In some cases, shown forced diuresis, accelerating the withdrawal of hazardous substances. To this end, the patient drinks a large amount of water and takes diuretics.
  4. In the conditions of a hospital is conducted AMLO. Detoxification takes 6-8 hours. The method is useful in the initial stages of dependence.
  5. Drug treatment and hardware procedures. It is also held in a hospital.


Centrally acting synthetic opioid analgesic, an agonist of μ, di k receptors. It also shows antitussive activity. It inhibits the reversible uptake of norepinephrine and serotonin in the synapses of the descending pain conduction system in the spinal cord. When given orally, it works about 5 times weaker than the morphine used after, parenterally administered works about 10 times weaker than parenteral morphine. 

After postprandial administration, it is well absorbed from the gastrointestinal tract; the bioavailability is 75%, t max after administration in a standard release form – about 2 hours, t max after administration in prolonged release form about 5 hours in 20% bound to plasma proteins.

 Analgesic activity starts 15-30 minutes after administration and usually lasts 3-4 hours. The action of prolonged-release tablets persists for 6-8 hours.

It passes through the placenta and in a small percentage it is excreted in the female diet and metabolized in the liver with the participation of cytochrome P-450, including to the active form of O-desmethyl tramadol, having an affinity for μ receptors and potency greater than the parent compound. T 1/2 tramadol is 5-6 h, t 1/2 O-desmethyl tramadol – about 7.5 h.

In people with renal, hepatic or elderly failure t 1/2 is prolonged. It is excreted by the kidneys (in 90%) and in a smaller percentage with feces.


Acute and chronic post-traumatic and post-operative pain and cancer. In premedication, analgesia, obstetrics, in coronary pain. In palliative care, used to treat acute and chronic pain, also with a neuropathic component; is an opioid analgesic used on the 2nd level of the WHO ladder in the treatment of moderate to severe pain.


Hypersensitivity to any of the ingredients. Willingness to abuse addictive drugs. Poisoning with ethanol, sleeping pills, psychotropic drugs, painkillers. Do not administer MAO inhibitors to those currently on treatment or for the last 14 days

Caution in patients with epilepsy, people with liver or kidney failure (in the case of severe renal failure is not recommended), in conditions associated with increased intracranial pressure, in consciousness disorders of unknown cause, in the case of an increased risk of respiratory disorders. It is not recommended for children up to 12 years of age. Do not use in the treatment of opioid addiction.


Drugs that inhibit the CNS (hypnotics, sedative, psychotropic) and ethanol increase the side effects of tramadol. The use of tramadol in parallel with inhibitors of reuptake of serotonin, tricyclic antidepressants, antipsychotics or other drugs that lower the seizure threshold increases the risk of seizures.

 Carbamazepine accelerates the metabolism of tramadol; parallel treatment with tramadol is not recommended in patients receiving carbamazepine; if tramadol is needed in patients treated with carbamazepine> 800 mg / d, the tramadol dose should be increased. 

No interaction was observed with cimetidine or quinidine. Do not use in parallel with opioids acting agonist-antagonist. Parallel use with MAO inhibitors may be the cause of life-threatening side effects; tramadol administration may be started 2 weeks after discontinuation of MAO inhibitors.

Side effects

  • Dizziness
  • nausea and vomiting
  • constipation
  • tiredness and bewilderment
  • limitation of psychophysical fitness
  • dry mouth
  • excessive sweating
  •  Skin reactions (pruritus, urticaria)
  • gastrointestinal disorders. 

After two fast administration and in those who are weakened or after physical exercise may experience cardiovascular dysfunction (arrhythmias, tachycardia, orthostatic hypotension, syncope). 

Very rarely skeletal muscle weakness, appetite disturbances, urination disorders. Extremely rare mood disorders, changes in activity, changes in the ability to feel and recognize, increase in blood pressure, bradycardia, worsening of bronchial asthma, hypersensitivity reactions, anaphylactic shock. In patients with hypertension, the possibility of a drop in blood pressure. 

The drug increases the risk of seizures, especially at doses higher than recommended, and also when used in parallel with drugs that lower the seizure threshold, neuroleptics, selective serotonin reuptake inhibitors, tricyclic antidepressants, other opioids, and MAO inhibitors. 

The drug may cause addiction (low addictive potential), after abrupt withdrawal symptoms of abstinence may occur. Overdose can lead to respiratory depression by paralysis of the respiratory center: antidote – naloxone. Hemodialysis and haemofiltration only remove the drug from the blood in a minimal percentage.

Pregnancy and lactation

Category C. The drug crosses the placenta; in pregnant women, use only temporarily, if the benefit of the treatment outweighs the potential risk to the fetus; in the case of long-term use, dependence and subsequent withdrawal symptoms in the newborn can not be excluded. 

The drug is excreted in human milk (about 0.1% of the dose); Do not use chronically during breastfeeding.


Caps. And drops: adults and children after 12 years 50-100 mg, the dose can be repeated every 4-6 h, children 1-12. 1-2 mg/kg, max. 8 mg/kg/ day; in children, the recommended form of the drug drops. 

Table. And prolonged releases: adults and children after 12 years of age usually 100-200 mg 1-2 × / d. Pr adults and children after 12 years. 100 mg 2-3 × / d. Parenteral (iv, im, sc ) adults and children aged 12 to 50-100 mg, the dose can be repeated every 4-6 h, children 1.-12. 1-2 mg/kg Do not exceed, except in exceptional cases, a daily dose of 400 mg. In people with moderate renal insufficiency, the dosing interval should be increased.


Tramadol is the most dangerous drug from the group of opioids, which leads to severe mental and physical dependence.

An addiction treatment program is always developed individually. The treatment is entirely anonymous.